羔羊组 – 最高信仰研究小组，长寿永生

A new drug-like molecule increases lifespan in worms, improves pathology and enhances function in mammalian muscles cells

Healthy mitochondria are the organelles in our cells that produce energy. This is true for humans as well as C. elegans (a small, short-lived, nematode used to study aging).

Researchers at Buck Institute identified a new druglike molecule which keeps mitochondria healthy through mitophagy. Mitophagy is a process in which damaged mitochondria are removed and recycled by multicellular organisms. The compound MIC is a natural substance that has extended the lifespan of C. elegans and ameliorated neurodegenerative disease in C. elegans models. It also improved mitochondrial function within mouse muscle cells. The results will be published in Nature Aging’s November 13th, 2023 edition.

A defect in mitophagy may be responsible for many age-related illnesses. It is linked to neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and heart failure. It also influences metabolic disorders like obesity and type 2 diabetics.

来源和详细信息：
https://medicalxpress.com/news/2023-11-drug-like-molecule-lifespan-ameliorates-pathology.html

New molecule promoting healthy mitochondria via mitophagy found

Mitophagy inducing compound (MIC), a naturally occurring compound found in plants, can help combat age-related illnesses by promoting mitochondrial function through mitophagy.

Mohammed Haneefa Nizamudeen / iStock.

Scientists have stated that mitophagy involves the removal and recycling of damaged mitochondria from multicellular organisms.

来源和详细信息：
https://interestingengineering.com/health/new-molecule-promotes-healthy-mitochondria

Conquer Aging or Die Trying Podcast, Episode #1: Crissman Loomis (@Unaging.com)
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来源和详细信息：

Super Melanin heals skin injuries from sunburns, chemical burns

Imagine a cream that can heal skin damage caused by environmental toxins or sunlight. Scientists at Northwestern University have developed a biomimetic, synthetic melanin that could be used to heal skin damage.

In a recent study, scientists have shown that their synthetic, melanin mimicking the melanin found in the human skin can be applied topically on injured skin to accelerate wound healing. These effects are seen both on the skin and throughout the body.

Scientists said that when applied as a cream, synthetic melanin protects the skin from the sun and heals the skin damaged by sun damage or chemical burning. The technology works by scavenging the free radicals that are produced when skin is injured, such as by sunburn. Unchecked free radical activity can damage cells, resulting in skin cancer and aging.

来源和详细信息：

‘Super Melanin’ Heals Skin Injuries from Sunburn, Chemical Burns

Bryan Johnson explains his daily routine to Fortune Magazine in Spanish
Bryan Johnson’s daily routine Cortesy Fortune Magazine

The video was first published in Fortune Magazine, March 27, 2023.

The article’s title is \”The strict antiaging routine of 45-year old CEO who spends millions per year to look 18 again – from diet to exercise\”.

You can read the entire article by clicking here: https://fortune.com/well/2023/03/19/bryan-johnson-anti-aging…-exercise/

来源和详细信息：

How long can humans survive? #longevity #healthspan #lifespan

来源和详细信息：

A study reveals that a bacterial protein can keep human cells healthy

Researchers from the University of Sao Paulo in Brazil have discovered a novel protein produced by bacteria that is capable of keeping human cells healthy, even when they are under a heavy burden of bacteria. This discovery could lead new treatments for many diseases related to mitochondrial dysfunction such as cancers and auto-immune conditions. Mitochondria, which are organelles in cells that provide most of the energy for biochemical reactions within cells, are the source of this chemical energy.

The study was published in PNAS. Researchers analyzed 130 of the proteins that Coxiella burnetii releases when it invades host cells. They found at least one protein capable of prolonging cellular longevity by directly acting on mitochondria.

C. burnetii, after invading the host cell, releases a protein that was previously unknown, called mitochondrial coxiella-effector F (MceF) by the authors. MceF interacts glutathione-peroxidase 4(GPX4) an antioxidant enzyme found in mitochondria to improve mitochondrial functions by promoting anti-oxidizing effects that prevent cell damage and death.

来源和详细信息：
https://phys.org/news/2023-11-reveals-bacterial-protein-capable-human.html

Let’s all get better at playing don’t Die every day.

Bryan Johnson, the most famous biohacker in the world and possibly the \”most measured person in human history\”, is a man of many talents. Bryan Johnson is on a quest to reverse the biological age of all 70 of his organs to extend his life and improve his health. He will then share his protocol to allow others to benefit from his research, experience and experiments.

Johnson’s philosophy can be summarized as \”don’t die.\” To that end, his book or novel entitled Don’t Die is available as a free eBook from his website. The uncorrected version of the advanced reading edition is also available. Johnson’s pseudonym for this project is Zero. He describes himself as \”the first individual H. sapiens who has exceeded five hundred years old,\” and dies in 2 478 by accident rather than through old age. This leaves him just weeks from becoming \”Homo Deus.\” Johnson also credits Zero with inventing Zeroism, the resurrection technology undie and fathering \”millions\” of biological and digital descendants who live \”in the far reaches and beyond the solar system.\”

Longevity. Technology: Since Don’t Die was written as a novel, Johnson could explore his philosophy a little differently. He invited us to watch the narrator Scribe on his final day on Earth. As he muses about humanity’s evolution in the future, the nature and impact of free will, and age reversal, and programmable biological. Scribe is joined in the story by characters from Pilgrim’s Progress, such as Cognitive Bias and Dark Humor, Game Play, and Self Critical.

来源和详细信息：

‘We all play don’t die every day – now let’s get really, really good at it’