月度归档： 2024 年 3 月

Alzheimer’s Disease: Proteins can predict signs and symptoms

Cross-sectional proteomic analysis showed that markers of Alzheimer’s and neurodegeneration were associated with protein indicators of subclinical health in plasma.

Researchers at the National Institute on Aging, Baltimore, found that higher levels of plasma biomarkers for amyloid beta, phosphorylated Tau181 (ptau181) and neurofilament (NfL), a measure neuronal damage, and glial fibrillary acidsic protein (GFAP), a measure astrogliosis, were associated with a greater risk of cardiovascular disease and heart failure mortality.

Walker and co-authors in Annals of Neurology found that ptau181, NfL and GFAP were also related to proteomic indicators of lean body mass and visceral fatty tissue.

来源和详细信息：
https://www.medpagetoday.com/neurology/dementia/107467

David Sinclair: Aging is now optional
The advancements in gene therapy, genetic engineering and anti-aging studies may allow age reversal, as well as the restoration of youthful health.

What is the main idea of the video clip?
The key idea here is that advances in anti-aging and genetic engineering research could eventually lead to age reversal, and the restoration and maintenance of youthful health.

How can you reverse the aging process?
It is possible to reverse the effects of ageing by rejuvenating the mind, restoring memory and learning ability, and addressing loss of inherited data through genetic engineering and epigenetic programming.

来源和详细信息：
https://digitalhabitats.global/blogs/news/aging-is-now-optional-w-david-sinclair-ep-60

GLS1 inhibitor eliminates senescent senescent cell and ameliorates age-related disorders

Year 2021 face_with_colon_three

Senescent cells can accumulate in the organs of aging people, causing tissue dysfunction and a variety of aging-related illnesses like cancer. Cells are formed by a process known as \”cellular senescence\”, a permanent cell-cycle arrest caused by multiple stressors.

Researchers led by Professor Makoto Nakaishi of The Institute of Medical Science at The University of Tokyo, IMSUT (IMSUT), have developed an inhibitor of glutamate metabolism enzyme GLS1, so that it can be administered to eliminate senescent senescent cell in vivo.

The researchers confirmed that GLS1 inhibited senescent cell accumulation in various organs and tissue of aged mice. This improved symptoms associated with age-associated tissue dysfunction, such as obesity diabetes, arteriosclerosis and NASH. This research was published in Science on January 15, 2020.

来源和详细信息：
https://www.news-medical.net/news/20210205/GLS1-inhibitor-selectively-eliminates-senescent-cells-ameliorates-age-associated-disorders.aspx

New study reveals chemical methods to reverse ageing and restore cell function

A new paper in Aging was published on July 12, 2023. It is titled \”Chemically-induced reprogramming for cellular aging reverse.\”

BUFFALO (NY) – 12 July 2023: Researchers have opened a new front in the battle against ageing and age-related illnesses. A team of Harvard Medical School scientists conducted the study. They published the first chemical method to reprogram cells into a youthful state. This was previously only possible with a powerful form of gene therapy.

On July 12, 2023 researchers Jae-Hyun Yang and Christopher A. Petty, Thomas Dixon McDougall Maria Vina Lopez Alexander Tyshkovskiy Sun Maybury Lewis Zhilichen Matthew Arnold Jien Li Oswaldo A. Martinez Alexander Behn Ryan Roger-Hammond Suzanne Angeli Vadim N.

来源和详细信息：
https://www.eurekalert.org/news-releases/995372

GLS1 inhibitors that remove senescent senescent cell selectively improved age-related tissue dysfunctions and diseases like arteriosclerosis

face_with_colon_three year 2021.

UTokyo People NAKANISH Makoto

UTokyo People JOHMURA Yoshikazu

Division of Cancer Cell Biology (IMSUT).

来源和详细信息：
https://www.ims.u-tokyo.ac.jp/imsut/en/about/press/page_00031.html

Artificial intelligence is a new tool for building and repairing roads and bridges.

A.I. A.I. Is it wise?

来源和详细信息：
https://www.nytimes.com/2023/11/19/us/ai-infrastructure-construction.html

A aging expert believes humans can live for 20,000 years. He’s not crazy

It would be wonderful!

One key is the key to unlocking long-term longevity.

来源和详细信息：
https://www.popularmechanics.com/science/health/a44713943/humans-can-live-20000-years-aging-expert/

Scientists have developed a protein that improves memory

Researchers at the Catholic University of Rome’s Faculty of Medicine and Surgery and the Fondazione Policlinico Universitario A. Gemelli IRCCS developed a protein engineered to boost memory.

Scientists from the Faculty of Medicine and Surgery of Catholic University in Rome and the Fondazione Universitario Agustino Gemelli, IRCCS, have genetically altered a molecule called LIMK1, a protein that is normally active in brain cells and plays a crucial role in memory.

Rapamycin is a drug that has anti-aging properties in the brain.

来源和详细信息：

Scientists Have Developed an Engineered Protein That Improves Memory