Stem Cells as Potential Aging Research Tools | Dr. Elena Seranova Interview Series Ep3

Dr Elena Seranova Interview Series Ep3
Particularly, I enjoy the 3D modelling segment.

Here, Dr Seranova discusses the use of stem cells in research on diseases associated with aging. She focuses specifically on the generation of organiods for the brain using stem cells.
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Dr. Seranova, a serial entrepreneur and MSc in Translational Neuroscience, has a PhD in Stem Cell Biology, and Autophagy, from the University of Birmingham in the UK.

Chapters.
00:00 Success rate of clinical trials.
02:10 Ageing as a condition.
Why do clinical studies fail?
Using stem cell in 3D
9:00 Efficiency in research
11:45 Organoid Formation

This video contains links.
NMN Bio website: https://nmnbio.co.uk/
NAD depletion is associated with cytotoxicity of human neurons that are autophagy-deficient.
https://www.sciencedirect.com/science/article/pii/S2211124723003832
Autophagy increases cell survival through NAD.
https://pubmed.ncbi.nlm.nih.gov/36413951/
Nicotinamide mononucleotide reduces Alzheimer’s by regulating the intestinal microbiota.
https://sciencedirect.com/science/article/abs/pii/S0006291X23006538
Nicotinamide mononucleotide inhibits JNK activity to reverse Alzheimer’s disease.
https://pubmed.ncbi.nlm.nih.gov/28330719/

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Health claims Disclaimer: The information provided in this video does not replace direct medical treatment or individual advice. Consult your doctor before using this video. This video does not recommend any products or services.

来源和详细信息:
https://youtube.com/watch?v=wZ2uyzubuHw&si=5L-UEKhl5k7DaiVM

Unlocking Potential: Immortal Jellyfish DNA’s Role in Extending Human Life.

Jellyfish DNA could extend human life by extending the lifespan.

Researchers at the Eotvos-Lorand University have made a breakthrough in their understanding of how we age.

Researchers Adam Sturm and Tibor Vellai of Eotvos Lorand University, Hungary, have made a major discovery in the field of aging. They focused their research on \”transposable element\” (TEs), which are found in our DNA.

Deoxyribonucleic Acid, also known as DNA, is a molecule made up of two nucleotide strands that form a double-helix. DNA is the genetic material that is carried by humans and most other organisms. It contains instructions on growth, development, function, and reproduction. Nearly all cells in the body of a human have the same DNA. The majority of DNA is found in the nucleus, where it is known as nuclear DNA. However, a small amount can be found in mitochondrial DNA (also called mtDNA).

来源和详细信息:

Aging Reimagined: How “Immortal” Jellyfish DNA Could Extend Human Life

Nanotechnology as a Tool for Mind Control

Controlling the mind with nanotechnology

Maples Scientific Publisher brings you the latest original research, analysis, reviews, news, practice updates and thought-provoking editorials.

来源和详细信息:
https://maplespub.com/article/Control-of-Mind-using-Nanotechnology

Unlocking the Secrets of Aging with Epigenetic Test #9: A Younger Horvath Age Than the Chronological

The Chronological Age is Not the Only Way to Determine Horvath’s Age.
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来源和详细信息:

Protein Indicators and Alzheimer’s Risk

Alzheimer’s Disease: Proteins can predict signs and symptoms

Cross-sectional proteomic analysis showed that markers of Alzheimer’s and neurodegeneration were associated with protein indicators of subclinical health in plasma.

Researchers at the National Institute on Aging, Baltimore, found that higher levels of plasma biomarkers for amyloid beta, phosphorylated Tau181 (ptau181) and neurofilament (NfL), a measure neuronal damage, and glial fibrillary acidsic protein (GFAP), a measure astrogliosis, were associated with a greater risk of cardiovascular disease and heart failure mortality.

Walker and co-authors in Annals of Neurology found that ptau181, NfL and GFAP were also related to proteomic indicators of lean body mass and visceral fatty tissue.

来源和详细信息:
https://www.medpagetoday.com/neurology/dementia/107467

Unlocking the Potential of Age Reversal: Exploring Anti-Aging and Genetic Engineering As Future Solutions

David Sinclair: Aging is now optional
The advancements in gene therapy, genetic engineering and anti-aging studies may allow age reversal, as well as the restoration of youthful health.

What is the main idea of the video clip?
The key idea here is that advances in anti-aging and genetic engineering research could eventually lead to age reversal, and the restoration and maintenance of youthful health.

How can you reverse the aging process?
It is possible to reverse the effects of ageing by rejuvenating the mind, restoring memory and learning ability, and addressing loss of inherited data through genetic engineering and epigenetic programming.

来源和详细信息:
https://digitalhabitats.global/blogs/news/aging-is-now-optional-w-david-sinclair-ep-60

GLS1 Inhibitors Show Promise in Eliminating Senescent Cells and Alleviating Age-Associated Disorders

GLS1 inhibitor eliminates senescent senescent cell and ameliorates age-related disorders

Year 2021 face_with_colon_three

Senescent cells can accumulate in the organs of aging people, causing tissue dysfunction and a variety of aging-related illnesses like cancer. Cells are formed by a process known as \”cellular senescence\”, a permanent cell-cycle arrest caused by multiple stressors.

Researchers led by Professor Makoto Nakaishi of The Institute of Medical Science at The University of Tokyo, IMSUT (IMSUT), have developed an inhibitor of glutamate metabolism enzyme GLS1, so that it can be administered to eliminate senescent senescent cell in vivo.

The researchers confirmed that GLS1 inhibited senescent cell accumulation in various organs and tissue of aged mice. This improved symptoms associated with age-associated tissue dysfunction, such as obesity diabetes, arteriosclerosis and NASH. This research was published in Science on January 15, 2020.

来源和详细信息:
https://www.news-medical.net/news/20210205/GLS1-inhibitor-selectively-eliminates-senescent-cells-ameliorates-age-associated-disorders.aspx

Revolutionizing Aging: Groundbreaking Chemical Discovery to Reverse Cellular Aging and Restore Function

New study reveals chemical methods to reverse ageing and restore cell function

A new paper in Aging was published on July 12, 2023. It is titled \”Chemically-induced reprogramming for cellular aging reverse.\”

BUFFALO (NY) – 12 July 2023: Researchers have opened a new front in the battle against ageing and age-related illnesses. A team of Harvard Medical School scientists conducted the study. They published the first chemical method to reprogram cells into a youthful state. This was previously only possible with a powerful form of gene therapy.

On July 12, 2023 researchers Jae-Hyun Yang and Christopher A. Petty, Thomas Dixon McDougall Maria Vina Lopez Alexander Tyshkovskiy Sun Maybury Lewis Zhilichen Matthew Arnold Jien Li Oswaldo A. Martinez Alexander Behn Ryan Roger-Hammond Suzanne Angeli Vadim N.

来源和详细信息:
https://www.eurekalert.org/news-releases/995372