分类： 新闻

Cutting back on one amino acid increases the life expectancy of middle-aged mice by up to 33%

In a new study, mice were given a limited amount of an essential amino acid that slowed down the effects of aging and extended their life span.

Scientists wonder if this research could improve longevity and quality-of-life.

Isoleucine, one of the three branched chain amino acids that we use in our body to make proteins, is one of these. Since our cells cannot produce it, we must get it through sources such as eggs, dairy products, soy proteins, and meats.

来源和详细信息：
https://www.sciencealert.com/cutting-back-on-one-amino-acid-increases-lifespan-of-middle-aged-mice-up-to-33

Serratia marcescens is still a problem in the oral microbiome tests #8 and 9.
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来源和详细信息：
https://www.youtube.com/watch?v=DkOceKds2a8

Dr Elena Seranova Interview Series Ep3
Particularly, I enjoy the 3D modelling segment.

Here, Dr Seranova discusses the use of stem cells in research on diseases associated with aging. She focuses specifically on the generation of organiods for the brain using stem cells.
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Dr. Seranova, a serial entrepreneur and MSc in Translational Neuroscience, has a PhD in Stem Cell Biology, and Autophagy, from the University of Birmingham in the UK.

Chapters.
00:00 Success rate of clinical trials.
02:10 Ageing as a condition.
Why do clinical studies fail?
Using stem cell in 3D
9:00 Efficiency in research
11:45 Organoid Formation

This video contains links.
NMN Bio website: https://nmnbio.co.uk/
NAD depletion is associated with cytotoxicity of human neurons that are autophagy-deficient.
https://www.sciencedirect.com/science/article/pii/S2211124723003832
Autophagy increases cell survival through NAD.
https://pubmed.ncbi.nlm.nih.gov/36413951/
Nicotinamide mononucleotide reduces Alzheimer’s by regulating the intestinal microbiota.
https://sciencedirect.com/science/article/abs/pii/S0006291X23006538
Nicotinamide mononucleotide inhibits JNK activity to reverse Alzheimer’s disease.
https://pubmed.ncbi.nlm.nih.gov/28330719/

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Health claims Disclaimer: The information provided in this video does not replace direct medical treatment or individual advice. Consult your doctor before using this video. This video does not recommend any products or services.

来源和详细信息：
https://youtube.com/watch?v=wZ2uyzubuHw&si=5L-UEKhl5k7DaiVM