分类： 新闻

Artificial intelligence is a new tool for building and repairing roads and bridges.

A.I. A.I. Is it wise?

来源和详细信息：
https://www.nytimes.com/2023/11/19/us/ai-infrastructure-construction.html

A aging expert believes humans can live for 20,000 years. He’s not crazy

It would be wonderful!

One key is the key to unlocking long-term longevity.

来源和详细信息：
https://www.popularmechanics.com/science/health/a44713943/humans-can-live-20000-years-aging-expert/

Scientists have developed a protein that improves memory

Researchers at the Catholic University of Rome’s Faculty of Medicine and Surgery and the Fondazione Policlinico Universitario A. Gemelli IRCCS developed a protein engineered to boost memory.

Scientists from the Faculty of Medicine and Surgery of Catholic University in Rome and the Fondazione Universitario Agustino Gemelli, IRCCS, have genetically altered a molecule called LIMK1, a protein that is normally active in brain cells and plays a crucial role in memory.

Rapamycin is a drug that has anti-aging properties in the brain.

来源和详细信息：

Scientists Have Developed an Engineered Protein That Improves Memory

Cambridge team creates blood vessels to study brain diseases

The disease of the cerebral small vessels is responsible for nearly half of all dementias worldwide.

Sudok1/iStock.

The study, published in Stem Cell Reports suggests a potential drug target for preventing or treating cerebral small vessel diseases (SVD).

来源和详细信息：
https://interestingengineering.com/health/cambridge-team-grows-blood-vessels-to-investigate-brain-diseases

Drug-Activated protein boosts memory

Researchers have made a breakthrough by genetically altering the LIMK1 (a protein crucial to memory) so that it can be controlled by rapamycin.

This study shows that it is possible to improve memory by manipulating the synaptic plasticity of the brain.

The engineered protein improved memory in animal models that had age-related cognitive decline. This could lead to innovative treatments for neuropsychiatric disorders like dementia. This ‘chemogenetic approach’, which combines genetics and chemical compounds, opens up new avenues for neurological research and treatment.

来源和详细信息：

Drug-Activated Protein Boosts Memory

A Slow Wave Sleep % loss is associated with an increased risk of dementia
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Max More: Cryonics and the Morality of Progress
If you would like to support this podcast, click here. Max More is an author, philosopher, futurist and former CEO of Alcor Life Extension Foundation. He is the Director of Communications for Biostasis Technology. Max was the author of the first modern definition of \”Transhumanism\”.

来源和详细信息：
https://arjunkhemani.substack.com/p/24-max-more-cryonics-transhumanism

A new drug-like molecule increases lifespan in worms, improves pathology and enhances function in mammalian muscles cells

Healthy mitochondria are the organelles in our cells that produce energy. This is true for humans as well as C. elegans (a small, short-lived, nematode used to study aging).

Researchers at Buck Institute identified a new druglike molecule which keeps mitochondria healthy through mitophagy. Mitophagy is a process in which damaged mitochondria are removed and recycled by multicellular organisms. The compound MIC is a natural substance that has extended the lifespan of C. elegans and ameliorated neurodegenerative disease in C. elegans models. It also improved mitochondrial function within mouse muscle cells. The results will be published in Nature Aging’s November 13th, 2023 edition.

A defect in mitophagy may be responsible for many age-related illnesses. It is linked to neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and heart failure. It also influences metabolic disorders like obesity and type 2 diabetics.

来源和详细信息：
https://medicalxpress.com/news/2023-11-drug-like-molecule-lifespan-ameliorates-pathology.html