A new drug-like molecule increases lifespan in worms, improves pathology and enhances function in mammalian muscles cells
Healthy mitochondria are the organelles in our cells that produce energy. This is true for humans as well as C. elegans (a small, short-lived, nematode used to study aging).
Researchers at Buck Institute identified a new druglike molecule which keeps mitochondria healthy through mitophagy. Mitophagy is a process in which damaged mitochondria are removed and recycled by multicellular organisms. The compound MIC is a natural substance that has extended the lifespan of C. elegans and ameliorated neurodegenerative disease in C. elegans models. It also improved mitochondrial function within mouse muscle cells. The results will be published in Nature Aging’s November 13th, 2023 edition.
A defect in mitophagy may be responsible for many age-related illnesses. It is linked to neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and heart failure. It also influences metabolic disorders like obesity and type 2 diabetics.
来源和详细信息：
https://medicalxpress.com/news/2023-11-drug-like-molecule-lifespan-ameliorates-pathology.html