作者： lausm

每天我都拉屎。
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ATR Kinase: Ensuring Telomerase Remains Stable

Cells keep telomerase under control: Study

It is hard to tell the difference between intact and broken spaghetti strands, but the natural ends of chromosomes look like DNA. Every cell in our body must be able to distinguish between the two, because the best method to repair damaged DNA is also the worst for protecting the healthy end.

Take the enzyme telomerase. It is responsible for maintaining protective end caps at the ends of chromosomes. If telomerase were to seal off a DNA strand with a telomere and prevent further repair, it would delete essential genes.

A new study published in Science explains how cells can avoid these mishaps. The findings indicate that telomerase could indeed be running amok and adding telomeres on damaged DNA. This would have happened if the ATR Kinase enzyme, which responds to DNA damages, was not present.

来源和详细信息：
https://phys.org/news/2024-02-reveals-cells-telomerase.html

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AI Tools Outshone Standard Clinical Method for Predicting Heart Transplant Rejection, Study Finds

AI tools are better than the standard clinical method at predicting rejection of heart transplants, according to a study

In 2023, more than 4,500 heart-transplants will be performed in the U.S. Organ rejection is a serious risk. While this life-saving procedure improves quality of life for many recipients and increases their longevity, it can also be a life-threatening operation.

Researchers from Emory University Case Western Reserve University, and the University of Pennsylvania have developed artificial intelligence tools that can be used to analyze cardiac biopsy images in order to better predict rejection. This will help to ensure that patients receive the best post-transplant care.

The histologic grading is used by clinicians to diagnose acute rejection. There are some limitations with this method. It assigns International Society of Heart and Lung Transplantation’s (ISHLT) histologic grade corresponding to mild, moderate and serious rejection.

来源和详细信息：
https://medicalxpress.com/news/2024-02-ai-tools-heart-transplant-standard.html

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Unveiling Neural Networks: Exploiting Novel Rabies Viral Vectors for Brain Mapping

Brain Mapping with Novel Rabies Viral vectors

Researchers have developed 20 novel recombinant viral vectors for mapping neural circuits in Alzheimer’s and aging studies. These vectors highlight microstructural differences in brain neurons by using enhanced fluorescent proteins. They provide insights into neural networks on both a micro and macro level.

They are powerful tools to dissect neural circuitry, both in a healthy and ill state. This innovation will open new treatment pathways and be shared with the neuroscientific community by UCI’s Center for Neural Circuit Mapping.

来源和详细信息：

Brain Mapping With Novel Rabies Viral Vectors

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Groundbreaking Study Demonstrates Evidence of Reverse Material Aging

Scientists find evidence that time is reversed in a historic study

Humans have been fascinated by the idea of time travel for thousands of year, but until recently it was a fiction.

Scientists have found evidence that time travel is real. Thomas Blochowicz and Till Bohmer are the authors of the new study Time reversibility when materials age. It was published in Nature Physics.

Two researchers from Darmstadt’s Technical University in Germany have been researching the’shifting’ of time in certain materials, such as glass.

来源和详细信息：
https://www.indy100.com/science-tech/scientists-evidence-time-travel-glass-2667265698