先须挽取银河水，后方栽种太华山
Cambridge team creates blood vessels to study brain diseases
The disease of the cerebral small vessels is responsible for nearly half of all dementias worldwide.
Sudok1/iStock.
The study, published in Stem Cell Reports suggests a potential drug target for preventing or treating cerebral small vessel diseases (SVD).
来源和详细信息：
https://interestingengineering.com/health/cambridge-team-grows-blood-vessels-to-investigate-brain-diseases
Drug-Activated protein boosts memory
Researchers have made a breakthrough by genetically altering the LIMK1 (a protein crucial to memory) so that it can be controlled by rapamycin.
This study shows that it is possible to improve memory by manipulating the synaptic plasticity of the brain.
The engineered protein improved memory in animal models that had age-related cognitive decline. This could lead to innovative treatments for neuropsychiatric disorders like dementia. This ‘chemogenetic approach’, which combines genetics and chemical compounds, opens up new avenues for neurological research and treatment.
来源和详细信息：
A Slow Wave Sleep % loss is associated with an increased risk of dementia
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来源和详细信息：
Max More: Cryonics and the Morality of Progress
If you would like to support this podcast, click here. Max More is an author, philosopher, futurist and former CEO of Alcor Life Extension Foundation. He is the Director of Communications for Biostasis Technology. Max was the author of the first modern definition of \”Transhumanism\”.
来源和详细信息：
https://arjunkhemani.substack.com/p/24-max-more-cryonics-transhumanism
A new drug-like molecule increases lifespan in worms, improves pathology and enhances function in mammalian muscles cells
Healthy mitochondria are the organelles in our cells that produce energy. This is true for humans as well as C. elegans (a small, short-lived, nematode used to study aging).
Researchers at Buck Institute identified a new druglike molecule which keeps mitochondria healthy through mitophagy. Mitophagy is a process in which damaged mitochondria are removed and recycled by multicellular organisms. The compound MIC is a natural substance that has extended the lifespan of C. elegans and ameliorated neurodegenerative disease in C. elegans models. It also improved mitochondrial function within mouse muscle cells. The results will be published in Nature Aging’s November 13th, 2023 edition.
A defect in mitophagy may be responsible for many age-related illnesses. It is linked to neurodegenerative diseases such as Parkinson’s, Alzheimer’s, and heart failure. It also influences metabolic disorders like obesity and type 2 diabetics.
来源和详细信息：
https://medicalxpress.com/news/2023-11-drug-like-molecule-lifespan-ameliorates-pathology.html
New molecule promoting healthy mitochondria via mitophagy found
Mitophagy inducing compound (MIC), a naturally occurring compound found in plants, can help combat age-related illnesses by promoting mitochondrial function through mitophagy.
Mohammed Haneefa Nizamudeen / iStock.
Scientists have stated that mitophagy involves the removal and recycling of damaged mitochondria from multicellular organisms.
来源和详细信息：
https://interestingengineering.com/health/new-molecule-promotes-healthy-mitochondria
Conquer Aging or Die Trying Podcast, Episode #1: Crissman Loomis (@Unaging.com)
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Super Melanin heals skin injuries from sunburns, chemical burns
Imagine a cream that can heal skin damage caused by environmental toxins or sunlight. Scientists at Northwestern University have developed a biomimetic, synthetic melanin that could be used to heal skin damage.
In a recent study, scientists have shown that their synthetic, melanin mimicking the melanin found in the human skin can be applied topically on injured skin to accelerate wound healing. These effects are seen both on the skin and throughout the body.
Scientists said that when applied as a cream, synthetic melanin protects the skin from the sun and heals the skin damaged by sun damage or chemical burning. The technology works by scavenging the free radicals that are produced when skin is injured, such as by sunburn. Unchecked free radical activity can damage cells, resulting in skin cancer and aging.
来源和详细信息：
‘Super Melanin’ Heals Skin Injuries from Sunburn, Chemical Burns