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Eric Topol
https://music.youtube.com/watch?v=n_LefGJgOJ8&si=UoInnL8Xy_wsXv_

Listening to this. He’s decent, right up there with Dr Daniel Amen when it comes to ideas and advancement. This episode was barely begun, but I’m learning that AI is a great tool for medicine. There are also more podcasts in this podcast about our own health. These are some of the key issues to longevity.

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View the Show Notes For This Episode: https://bit.ly/ep-855

Eric Topol, PhD, is Professor of Molecular Medicine and Executive Vice President of Scripps Research. He founded and directs the Scripps Research Translational Institute. He is a top-ten most-cited researcher in medicine, having published more than 1,200 peer reviewed articles, with over 330,000 citations. His main scientific focus is on individualized medicine, using genomic, digital and AI tools.

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来源和详细信息：
https://music.youtube.com/watch?v=n_LefGJgOJ8&si=UoInnL8Xy_wsXv_-

Reprogramming Cells to Rejuvenate

A recent review in Ageing Research Reviews summarises the research on epigenetic programming and its potential for rejuvenation therapy.

The epigenome changes with age. These changes can affect gene regulation and cellular homeostasis. They can also play a part in age-associated phenotypes. The addition or removal chemical groups from DNA or DNA-associated protein has a profound effect on gene expression, tissues functions and identity.

The authors of this review believe that epigenetic reprogramming is one of the most promising interventions currently available to delay or stop aging. It could even reverse it at the cell level. The authors believe epigenetics is the foundation of aging. Therefore, being able impact the epigenome will allow them to address several Hallmarks of Ageing simultaneously.

来源和详细信息：

Rejuvenating Cells with Epigenetic Reprogramming

ATR prevents telomerase converting DNA breaks to telomeres

ATR kinase signals are able to keep human telomerase in check. Telomerase adds telomeres on broken chromosomes, which threatens genome integrity.

来源和详细信息：
https://www.science.org/doi/10.1126/science.adg3224

Discovered a molecular pathway that controls aging

Researchers at the State University of Campinas (UNICAMP) in Brazil found that exchanging RNA molecules is one of the ways different types of cells communicate. Researchers at the State University of Campinas in Brazil have found that the lifespan of roundworms of Caenorhabditis species is reduced when the communication pathway is disrupted.

Gene published an article about the study. The study contributes to a better knowledge of the aging and diseases associated with it.

Previous research has shown that certain types of RNA are capable of being transferred from one cell into another. This allows for intertissue communication of the type that occurs when proteins and metabolites are present, for instance. This is a signaling mechanism between neighboring or adjacent cells. This is part of [the physiopathology] of many diseases, and of an organism’s normal function,\” said Marcelo Mori. He’s a professor and the article’s corresponding author at the Institute of Biology.

来源和详细信息：
https://phys.org/news/2024-02-important-molecular-pathway-aging.html

Cells keep telomerase under control: Study

It is hard to tell the difference between intact and broken spaghetti strands, but the natural ends of chromosomes look like DNA. Every cell in our body must be able to distinguish between the two, because the best method to repair damaged DNA is also the worst for protecting the healthy end.

Take the enzyme telomerase. It is responsible for maintaining protective end caps at the ends of chromosomes. If telomerase were to seal off a DNA strand with a telomere and prevent further repair, it would delete essential genes.

A new study published in Science explains how cells can avoid these mishaps. The findings indicate that telomerase could indeed be running amok and adding telomeres on damaged DNA. This would have happened if the ATR Kinase enzyme, which responds to DNA damages, was not present.

来源和详细信息：
https://phys.org/news/2024-02-reveals-cells-telomerase.html

AI tools are better than the standard clinical method at predicting rejection of heart transplants, according to a study

In 2023, more than 4,500 heart-transplants will be performed in the U.S. Organ rejection is a serious risk. While this life-saving procedure improves quality of life for many recipients and increases their longevity, it can also be a life-threatening operation.

Researchers from Emory University Case Western Reserve University, and the University of Pennsylvania have developed artificial intelligence tools that can be used to analyze cardiac biopsy images in order to better predict rejection. This will help to ensure that patients receive the best post-transplant care.

The histologic grading is used by clinicians to diagnose acute rejection. There are some limitations with this method. It assigns International Society of Heart and Lung Transplantation’s (ISHLT) histologic grade corresponding to mild, moderate and serious rejection.

来源和详细信息：
https://medicalxpress.com/news/2024-02-ai-tools-heart-transplant-standard.html

Longevity diet for dogs

It seems that caloric restriction is the best diet for dogs to prolong their life span, just as it is in other species.

What is the best diet for dog longevity? We studied the science behind dry kibbles, raw food, and caloric restrictions and found that there was a clear winner.

来源和详细信息：

Best Dog Longevity Diet

Brain Mapping with Novel Rabies Viral vectors

Researchers have developed 20 novel recombinant viral vectors for mapping neural circuits in Alzheimer’s and aging studies. These vectors highlight microstructural differences in brain neurons by using enhanced fluorescent proteins. They provide insights into neural networks on both a micro and macro level.

They are powerful tools to dissect neural circuitry, both in a healthy and ill state. This innovation will open new treatment pathways and be shared with the neuroscientific community by UCI’s Center for Neural Circuit Mapping.

来源和详细信息：

Brain Mapping With Novel Rabies Viral Vectors